SPD304 dihydrochloride( —— )

Catalog No. M26460 CAS No. 1049741-03-8

SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 μM. SPD304 dihydrochloride promotes dissociation of TNF trimers.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

SPD304 dihydrochloride
Note

Research use only, not for human use.
Brief Description

SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 μM. SPD304 dihydrochloride promotes dissociation of TNF trimers.
Description

SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 μM. SPD304 dihydrochloride promotes dissociation of TNF trimers.(In Vitro):The survivability of aHSCs is significantly rescued by SPD304 dihydrochloride (2 μM). The production of lipid hydroxides and intracellular GSH are increased as well. GA (75 μM) and SPD304 dihydrochloride (2 μM) downregulate TRADD (almost 2-fold) and p RIP3 (1.4 fold) compared to GA and promote the activation of caspase 8.
In Vitro

SPD304 (2 μM) significantly rescues the survivability of aHSCs, reduces the production of lipid hydroxides, and increased intracellular GSH. The co-treatment of GA (75 μM) and SPD304 (2 μM), down-regulate TRADD almost 2-fold (w/o inhibitor vs. w/ inhibitor) and p?RIP3 1.4?fold compared to GA alone, and promotes caspase 8 activation.
In Vivo

SPD304 cannot be used in vivo due to its high toxicity.
Synonyms

——
Pathway

Apoptosis
Target

TNF
Recptor

AP-1
Research Area

——
Indication

——

Chemical Information

CAS Number

1049741-03-8
Formula Weight

620.54
Molecular Formula

C32H34Cl2F3N3O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 11.36 mg/mL (18.31 mM)
SMILES

Cl.Cl.CN(CCN(C)Cc1coc2cc(C)c(C)cc2c1=O)Cc1cn(-c2cccc(c2)C(F)(F)F)c2ccccc12
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.C Huang, et al. Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. Proc Natl Acad Sci U S A. 1997 May 27;94(11):5826-30.

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